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Anti-CD223 Rabbit Monoclonal Antibody

     
  •  - Anti-CD223 Rabbit Monoclonal Antibody ABO16687
    Immunofluorescent analysis using the Antibody at 1:50 dilution.
    detail
  •  - Anti-CD223 Rabbit Monoclonal Antibody ABO16687
    Immunofluorescent analysis using the Antibody at 1:150 dilution.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC
Primary Accession P18627
Host Rabbit
Isotype Rabbit IgG
Reactivity Human
Clonality Monoclonal
Format Liquid
Description Anti-CD223 Rabbit Monoclonal Antibody . Tested in IHC, ICC/IF applications. This antibody reacts with Human.
Additional Information
Gene ID 3902
Other Names Lymphocyte activation gene 3 protein, LAG-3, CD223, Secreted lymphocyte activation gene 3 protein, sLAG-3, LAG3 (HGNC:6476), FDC
Calculated MW 57449 Da
Application Details IHC 1:50-1:200
ICC/IF 1:50-1:200
Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names Clone: 31L58
Immunogen A synthesized peptide derived from human CD223
Purification Affinity-chromatography
Storage Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Information
Name LAG3 (HGNC:6476)
Synonyms FDC
Function Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:20421648, PubMed:7805750, PubMed:8647185). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:20421648, PubMed:7805750, PubMed:8647185). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).
Cellular Location [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein
Tissue Location Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
Research Areas
Citations (0)
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$ 370.00
Cat# ABO16687
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