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> home > Products > Primary Antibodies > Cell Biology > Anti-Ube1L / UBA7 Rabbit Monoclonal Antibody
Anti-Ube1L / UBA7 Rabbit Monoclonal Antibody
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Application 
| WB, IHC, FC |
|---|---|
| Primary Accession | P41226 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Ube1L / UBA7 Rabbit Monoclonal Antibody . Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 7318 |
|---|---|
| Other Names | Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-activating enzyme 7, 6.2.1.-, D8, Ubiquitin-activating enzyme E1 homolog, UBA7 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:12471} |
| Calculated MW | 111694 Da |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 FC 1:50 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 31U08 |
| Immunogen | A synthesized peptide derived from human Ube1L / UBA7 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | UBA7 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:12471} |
|---|---|
| Function | E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation (PubMed:27545325). Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus (PubMed:16254333, PubMed:19073728, PubMed:29056542, PubMed:29743376, PubMed:37722521). For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition (PubMed:20133869). ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling (PubMed:27564865). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO16637
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