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> home > Products > Primary Antibodies > Signal Transduction > Anti-ABCD1 / ALD Rabbit Monoclonal Antibody
Anti-ABCD1 / ALD Rabbit Monoclonal Antibody
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Application 
| WB, FC |
|---|---|
| Primary Accession | P33897 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-ABCD1 / ALD Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 215 |
|---|---|
| Other Names | ATP-binding cassette sub-family D member 1 {ECO:0000312|HGNC:HGNC:61}, 3.1.2.-, 7.6.2.-, Adrenoleukodystrophy protein, ALDP, ABCD1 (HGNC:61), ALD |
| Calculated MW | 82937 Da |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 FC 1:50 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 30A99 |
| Immunogen | A synthesized peptide derived from human ABCD1 / ALD |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | ABCD1 (HGNC:61) |
|---|---|
| Synonyms | ALD |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)- CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP- dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP- dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:29397936, PubMed:33500543). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:21145416, PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity). |
| Cellular Location | Peroxisome membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi- pass membrane protein |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO16628
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