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Anti-BAG2 Antibody Picoband™ (monoclonal, 8F11G2)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O95816 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Anti-BAG2 Antibody Picoband™ (monoclonal, 8F11G2) . Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. |
| Reconstitution | Adding 0.2 ml of distilled water will yield a concentration of 500 µg/ml. |
| Gene ID | 9532 |
|---|---|
| Other Names | BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2 |
| Calculated MW | 24 kDa |
| Application Details | Western blot, 0.25-0.5 µg/ml, Human, Mouse Flow Cytometry, 1-3 µg/1x10^6 cells, Human |
| Contents | Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4. |
| Clone Names | Clone: 8F11G2 |
| Immunogen | E.coli-derived human BAG2 recombinant protein (Position: M1-N211). Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2. |
| Purification | Immunogen affinity purified. |
| Storage | At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. |
| Name | BAG2 |
|---|---|
| Function | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016). |
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Provided below are standard protocols that you may find useful for product applications.
Background
BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.
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