Anti-Phospho-p130(T986) Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IP |
---|---|
Primary Accession | Q08999 |
Host | Rabbit |
Isotype | IgG |
Reactivity | Human, Mouse |
Clonality | Monoclonal |
Format | Liquid |
Description | Anti-Phospho-p130(T986) Rabbit Monoclonal Antibody . Tested in WB, IP applications. This antibody reacts with Human, Mouse. |
Gene ID | 5934 |
---|---|
Other Names | Retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, RBL2, RB2 |
Calculated MW | 128 kDa |
Application Details | WB 1:500-1:2000 IP 1:50 |
Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Clone Names | Clone: 30R10 |
Immunogen | A synthesized peptide derived from human Phospho-p130(T986) |
Purification | Affinity-chromatography |
Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Name | RBL2 |
---|---|
Synonyms | RB2 |
Function | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
Cellular Location | Nucleus. |

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