Anti-Poliovirus Receptor/PVR Antibody Picoband™ (monoclonal, 5I13D1)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, FC |
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Primary Accession | P15151 |
Host | Mouse |
Isotype | Mouse IgG2a |
Reactivity | Human, Mouse |
Clonality | Monoclonal |
Format | Lyophilized |
Description | Anti-Poliovirus Receptor/PVR Antibody Picoband™ (monoclonal, 5I13D1) . Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse. |
Reconstitution | Adding 0.2 ml of distilled water will yield a concentration of 500 µg/ml. |
Gene ID | 5817 |
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Other Names | Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS |
Calculated MW | 70-80 kDa |
Application Details | Western blot, 0.25-0.5 µg/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 µg/ml, Human, Mouse Flow Cytometry, 1-3 µg/1x10^6 cells, Human |
Contents | Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4. |
Clone Names | Clone: 5I13D1 |
Immunogen | E.coli-derived human Poliovirus Receptor/PVR recombinant protein (Position: D28-E331). |
Purification | Immunogen affinity purified. |
Storage | At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. |
Name | PVR |
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Synonyms | PVS |
Function | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. |
Cellular Location | [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein [Isoform Beta]: Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that in humans is encoded by the PVR gene. The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
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