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Anti-SOD2 Antibody Picoband™ (monoclonal, 2B12B1)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P04179 |
| Host | Mouse |
| Isotype | Mouse IgG2b |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Anti-SOD2 Antibody Picoband™ (monoclonal, 2B12B1) . Tested in IHC, WB applications. This antibody reacts with Human, Mouse. |
| Reconstitution | Adding 0.2 ml of distilled water will yield a concentration of 500 µg/ml. |
| Gene ID | 6648 |
|---|---|
| Other Names | Superoxide dismutase [Mn], mitochondrial, 1.15.1.1, SOD2 |
| Calculated MW | 25 kDa |
| Application Details | Western blot, 0.25-0.5 µg/ml, Human, Mouse Immunohistochemistry(Paraffin-embedded Section), 2-5 µg/ml, Human |
| Contents | Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4. |
| Clone Names | Clone: 2B12B1 |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human SOD2, different from the related mouse sequence by one amino acid, and from the related rat sequence by four amino acids. |
| Purification | Immunogen affinity purified. |
| Storage | At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. |
| Name | SOD2 |
|---|---|
| Function | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
| Cellular Location | Mitochondrion matrix. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SOD2(Superoxide Dismutase 2), also called IPO-B or MNSOD, is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions occurring in mitochondria. This gene is a member of the iron/manganese superoxide dismutase family. Using a somatic cell hybrid panel containing different segments of chromosome 6, they demonstrated that SOD2 is located in the region 6q25.3-qter which, together with the FISH analysis, indicated that SOD2 is in the distal portion of 6q25. The SOD2 gene encodes an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation. Adeno-associated viral delivery of the human SOD2 gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion cells. The findings suggested that reactive oxygen species contributed to retinal cell death and optic nerve damage in mice with complex I deficiency, and that expression of SOD2 attenuated the disease process.
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