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Anti-GNG4 Antibody Picoband™ (monoclonal, 7B6)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P50150 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Rat, Mouse |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Anti-GNG4 Antibody Picoband™ (monoclonal, 7B6) . Tested in WB applications. This antibody reacts with Mouse, Rat. |
| Reconstitution | Adding 0.2 ml of distilled water will yield a concentration of 500 µg/ml. |
| Gene ID | 2786 |
|---|---|
| Other Names | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4, GNG4, GNGT4 |
| Calculated MW | 12 kDa |
| Application Details | Western blot, 0.25-0.5 µg/ml, Mouse, Rat |
| Contents | Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4. |
| Clone Names | Clone: 7B6 |
| Immunogen | E.coli-derived human GNG4 recombinant protein (Position: M1-D52). |
| Purification | Immunogen affinity purified. |
| Storage | At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. |
| Name | GNG4 |
|---|---|
| Synonyms | GNGT4 |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
| Tissue Location | Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene. This gene encodes the gamma subunit of the heterotrimeric G-proteins that are comprised of alpha, beta and gamma subunits. Upon activation by G protein-coupled receptors, the beta-gamma heterodimer dissociates from the alpha subunit to activate downstream signaling events. Alternate splicing results in multiple transcript variants.
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