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> home > Products > Primary Antibodies > Signal Transduction > Anti-PPP6C Rabbit Monoclonal Antibody
Anti-PPP6C Rabbit Monoclonal Antibody
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Application 
| WB, IF, ICC, FC |
|---|---|
| Primary Accession | O00743 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-PPP6C Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human. |
| Gene ID | 5537 |
|---|---|
| Other Names | Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, 3.1.3.16, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C {ECO:0000303|PubMed:29053956, ECO:0000312|HGNC:HGNC:9323} |
| Calculated MW | 32 kDa |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 FC 1:50 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 27P53 |
| Immunogen | A synthesized peptide derived from human PPP6C |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PPP6C {ECO:0000303|PubMed:29053956, ECO:0000312|HGNC:HGNC:9323} |
|---|---|
| Function | Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (PubMed:29053956). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32474700, PubMed:32753499). CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700). |
| Cellular Location | Mitochondrion. Cytoplasm |
| Tissue Location | Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. |
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$ 370.00
Cat# ABO16174
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