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> home > Products > Primary Antibodies > Signal Transduction > Anti-NUDT5 Rabbit Monoclonal Antibody
Anti-NUDT5 Rabbit Monoclonal Antibody
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Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9UKK9 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-NUDT5 Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 11164 |
|---|---|
| Other Names | ADP-sugar pyrophosphatase, 3.6.1.13, 8-oxo-dGDP phosphatase, 3.6.1.58, Nuclear ATP-synthesis protein NUDIX5, 2.7.7.96, Nucleoside diphosphate-linked moiety X motif 5, Nudix motif 5, hNUDT5, YSA1H, NUDT5, NUDIX5 {ECO:0000303|PubMed:27257257} |
| Calculated MW | 30 kDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 26N82 |
| Immunogen | A synthesized peptide derived from human NUDT5 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | NUDT5 |
|---|---|
| Synonyms | NUDIX5 {ECO:0000303|PubMed:27257257} |
| Function | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:17052728, PubMed:19699693, PubMed:21389046). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed. Most abundant in liver. |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO16103
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