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> home > Products > Primary Antibodies > Signal Transduction > Anti-ATGL / PNPLA2 Rabbit Monoclonal Antibody
Anti-ATGL / PNPLA2 Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q96AD5 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-ATGL / PNPLA2 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 57104 |
|---|---|
| Other Names | Patatin-like phospholipase domain-containing protein 2, 3.1.1.3, Adipose triglyceride lipase, Calcium-independent phospholipase A2-zeta, iPLA2-zeta, 3.1.1.4, Desnutrin, Pigment epithelium-derived factor receptor, PEDF-R, TTS2.2, Transport-secretion protein 2, TTS2, PNPLA2 (HGNC:30802) |
| Calculated MW | 55 kDa |
| Application Details | WB 1:500-1:2000 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 23P38 |
| Immunogen | A synthesized peptide derived from human ATGL / PNPLA2 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PNPLA2 (HGNC:30802) |
|---|---|
| Function | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3- diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). |
| Cellular Location | Lipid droplet. Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q8BJ56} |
| Tissue Location | Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level). |
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$ 370.00
Cat# ABO15762
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