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> home > Products > Primary Antibodies > Antibody Collections > Liver negative > Anti-CAD Rabbit Monoclonal Antibody
Anti-CAD Rabbit Monoclonal Antibody
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Application 
| WB, IF, ICC, IP, FC |
|---|---|
| Primary Accession | P27708 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-CAD Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human. |
| Gene ID | 790 |
|---|---|
| Other Names | Multifunctional protein CAD, Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase, Glutamine-dependent carbamoyl phosphate synthase, 6.3.5.5, Glutamine amidotransferase, GATase, GLNase, 3.5.1.2, Aspartate carbamoyltransferase, 2.1.3.2, Dihydroorotase, 3.5.2.3, CAD (HGNC:1424) |
| Calculated MW | 260 kDa |
| Application Details | WB 1:500-1:1000 ICC/IF 1:50-1:200 IP 1:30 FC 1:80 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 23C35 |
| Immunogen | A synthesized peptide derived from human CAD |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | CAD (HGNC:1424) |
|---|---|
| Function | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. |
| Cellular Location | Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO15759
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