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> home > Products > Primary Antibodies > Antibody Collections > SARS-Human interaction partners > Anti-Dkk3 Rabbit Monoclonal Antibody
Anti-Dkk3 Rabbit Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IF, ICC, IP |
|---|---|
| Primary Accession | Q9UBP4 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Dkk3 Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 27122 |
|---|---|
| Other Names | Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, REIC |
| Calculated MW | 60 kDa |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 IP 1:50 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 21D17 |
| Immunogen | A synthesized peptide derived from human Dkk3 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | DKK3 |
|---|---|
| Synonyms | REIC |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4} |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO15541
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