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> home > Products > Primary Antibodies > Signal Transduction > Anti-Langerin (CD207) Rabbit Monoclonal Antibody
Anti-Langerin (CD207) Rabbit Monoclonal Antibody
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Application 
| IHC |
|---|---|
| Primary Accession | Q9UJ71 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Langerin (CD207) Rabbit Monoclonal Antibody . Tested in IHC application. This antibody reacts with Human. |
| Gene ID | 50489 |
|---|---|
| Other Names | C-type lectin domain family 4 member K, Langerin, CD207, CD207, CLEC4K |
| Calculated MW | 36725 Da |
| Application Details | IHC 1:50-1:200 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 18C01 |
| Immunogen | A synthesized peptide derived from human Langerin (CD207) |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | CD207 |
|---|---|
| Synonyms | CLEC4K |
| Function | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. |
| Cellular Location | Membrane; Single- pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes |
| Tissue Location | Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. |
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Application Protocols
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$ 370.00
Cat# ABO15225
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