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> home > Products > Primary Antibodies > Signal Transduction > Anti-IP3 Receptor Rabbit Monoclonal Antibody
Anti-IP3 Receptor Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IP |
|---|---|
| Primary Accession | Q14643 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-IP3 Receptor Rabbit Monoclonal Antibody . Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 3708 |
|---|---|
| Other Names | Inositol 1, 4, 5-trisphosphate-gated calcium channel ITPR1, IP3 receptor isoform 1, IP3R 1, InsP3R1, Inositol 1, 4, 5 trisphosphate receptor, Inositol 1, 4, 5-trisphosphate receptor type 1, Type 1 inositol 1, 4, 5-trisphosphate receptor, Type 1 InsP3 receptor, ITPR1 {ECO:0000303|PubMed:7852357, ECO:0000312|HGNC:HGNC:6180} |
| Calculated MW | 313929 Da |
| Application Details | WB 1:500-1:2000 IHC 1:500-1:1000 IP 1:50 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 17I50 |
| Immunogen | A synthesized peptide derived from human IP3 Receptor |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | ITPR1 {ECO:0000303|PubMed:7852357, ECO:0000312|HGNC:HGNC:6180} |
|---|---|
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5- trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P29994, ECO:0000255} Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9TU34}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P29994, ECO:0000255}. Cytoplasm, perinuclear region. Note=Found in a complex with HSPA9 and VDAC1 at the endoplasmic reticulum-mitochondria contact sites. {ECO:0000250|UniProtKB:P29994} |
| Tissue Location | Widely expressed.. |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO15174
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