Anti-BNP Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P16860 |
Host | Rabbit |
Isotype | IgG |
Reactivity | Human |
Clonality | Monoclonal |
Format | Liquid |
Description | Anti-BNP Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human. |
Gene ID | 4879 |
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Other Names | Natriuretic peptides B, Brain natriuretic factor prohormone, preproBNP, BNP(4-32), BNP(4-31), BNP(4-30), BNP(4-29), BNP(4-27), BNP(5-32), BNP(5-31), BNP(5-29), NPPB |
Calculated MW | 14726 Da |
Application Details | WB 1:1000-1:5000 |
Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Clone Names | Clone: 17N42 |
Immunogen | A synthesized peptide derived from human BNP |
Purification | Affinity-chromatography |
Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Name | NPPB |
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Function | [Brain natriuretic peptide 32]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:1672777, PubMed:17372040, PubMed:1914098, PubMed:9458824). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed:21098034, PubMed:25339504, PubMed:9458824). Involved in regulating the extracellular fluid volume and maintaining the fluid- electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:1914098, PubMed:9458824). Binds the clearance receptor NPR3 (PubMed:16870210). |
Cellular Location | [NT-proBNP]: Secreted Note=Detected in blood. [Brain natriuretic peptide 32]: Secreted. Note=Detected in blood. |
Tissue Location | [Brain natriuretic peptide 32]: Detected in the cardiac atria (at protein level) (PubMed:2136732, PubMed:2138890) Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555). |
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