Anti- IL-9 Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P15248 |
Host | Mouse |
Isotype | Mouse IgG2b, κ |
Reactivity | Rat, Mouse |
Clonality | Monoclonal |
Format | Lyophilized |
Description | Anti- IL-9 Monoclonal Antibody . Tested in WB applications. This antibody reacts with Mouse, Rat. |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500 µg/ml. |
Gene ID | 3578 |
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Other Names | Interleukin-9, IL-9, Cytokine P40, T-cell growth factor P40, IL9 |
Calculated MW | 16 kDa |
Application Details | Western blot, 0.25-0.5&mu:g/ml, Mouse, Rat |
Protein Name | Interleukin-9 |
Contents | PBS, pH 7.0. Contains no stabilizers or preservatives |
Clone Names | Clone: AFID-9 |
Immunogen | Human IL-9 coupled to ovalbumin |
Purification | Immunogen affinity purified. |
Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Name | IL9 |
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Function | Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:29742432). Affects intestinal epithelial permeability and adaptive immunity (PubMed:29742432). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5. |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
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