Anti-Thioredoxin 2/TXN2 Antibody Picoband™ (monoclonal, 7B5)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, IF, ICC, FC |
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Primary Accession | Q99757 |
Host | Mouse |
Isotype | Mouse IgG2b |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Format | Lyophilized |
Description | Anti-Thioredoxin 2/TXN2 Antibody Picoband™ (monoclonal, 7B5) . Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene ID | 25828 |
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Other Names | Thioredoxin, mitochondrial, MTRX, Mt-Trx, Thioredoxin-2, TXN2, TRX2 |
Calculated MW | 14 kDa |
Application Details | Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 2 µg/ml, Human Flow Cytometry, 1-3 µg/1x10^6 cells, Human |
Subcellular Localization | Mitochondrion. |
Tissue Specificity | Widely expressed in adult (at protein level) and fetal tissues. |
Contents | Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
Clone Names | Clone: 7B5 |
Immunogen | E.coli-derived human Thioredoxin 2/TXN2 recombinant protein (Position: T60-G166). |
Purification | Immunogen affinity purified. |
Cross Reactivity | No cross-reactivity with other proteins. |
Storage | Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles. |
Name | TXN2 |
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Synonyms | TRX2 |
Function | Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. |
Cellular Location | Mitochondrion |
Tissue Location | Widely expressed in adult (at protein level) and fetal tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thioredoxin, mitochondrial also known as thioredoxin-2 is a protein that in humans is encoded by the TXN2 gene on chromosome 22. It is mapped to 22q12.3. This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
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