Anti-DMRT1 Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IP |
---|---|
Primary Accession | Q9Y5R6 |
Host | Rabbit |
Isotype | Rabbit IgG |
Reactivity | Human |
Clonality | Monoclonal |
Format | Liquid |
Description | Anti-DMRT1 Monoclonal Antibody . Tested in WB, IP applications. This antibody reacts with Human. |
Gene ID | 1761 |
---|---|
Other Names | Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1, DMT1 |
Calculated MW | 39473 Da |
Application Details | WB 1:500-1:2000 IP 1:80 |
Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Clone Names | Clone: AFCA-4 |
Immunogen | A synthesized peptide derived from human DMRT1 May be required for testis development. |
Purification | Affinity-chromatography |
Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Name | DMRT1 |
---|---|
Synonyms | DMT1 |
Function | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}. |
Tissue Location | Testis-specific. Expressed in prostate cancer (at protein level). |

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