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Anti-Myelin Basic Protein MBP Rabbit Monoclonal Antibody

     
  •  - Anti-Myelin Basic Protein MBP Rabbit Monoclonal Antibody ABO14277
    All lanes use the Antibody at 1:5K dilution for 1 hour at room temperature.
    detail
  •  - Anti-Myelin Basic Protein MBP Rabbit Monoclonal Antibody ABO14277
    All lanes use the Antibody at 1:5K dilution for 1 hour at room temperature.
    detail
  •  - Anti-Myelin Basic Protein MBP Rabbit Monoclonal Antibody ABO14277
    Western blot analysis of Myelin Basic Protein expression in Human fetal brain lysate.
    detail
  •  - Anti-Myelin Basic Protein MBP Rabbit Monoclonal Antibody ABO14277
    Immunohistochemical analysis of paraffin-embedded human brain, using Myelin Basic Protein Antibody.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P02686
Host Rabbit
Isotype Rabbit IgG
Reactivity Human
Clonality Monoclonal
Format Liquid
Description Anti-Myelin Basic Protein MBP Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human.
Additional Information
Gene ID 4155
Other Names Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP
Calculated MW 33117 MW KDa
Application Details WB 1:500-1:2000
IHC 1:50-1:200
Subcellular Localization Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic side of myelin.
Tissue Specificity MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system..
Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names Clone: IIE-13
Immunogen A synthesized peptide derived from human Myelin Basic Protein
Purification Affinity-chromatography
Storage Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Information
Name MBP
Function The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Cellular Location Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin
Tissue Location MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Research Areas
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$ 370.00
Cat# ABO14277
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