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> home > Products > Primary Antibodies > Signal Transduction > Anti-PI 3 Kinase Class 3 PIK3C3 Rabbit Monoclonal Antibody
Anti-PI 3 Kinase Class 3 PIK3C3 Rabbit Monoclonal Antibody
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Application 
| WB, IHC |
|---|---|
| Primary Accession | Q8NEB9 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-PI 3 Kinase Class 3 PIK3C3 Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 5289 |
|---|---|
| Other Names | Phosphatidylinositol 3-kinase catalytic subunit type 3, PI3-kinase type 3, PI3K type 3, PtdIns-3-kinase type 3, 2.7.1.137, Phosphatidylinositol 3-kinase p100 subunit, Phosphoinositide-3-kinase class 3, hVps34, PIK3C3 (HGNC:8974), VPS34 {ECO:0000305} |
| Calculated MW | 101549 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 |
| Subcellular Localization | Midbody. Late endosome. Cytoplasmic vesicle, autophagosome. As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (Probable). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).. |
| Tissue Specificity | Ubiquitously expressed, with a highest expression in skeletal muscle.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: CDO-16 |
| Immunogen | A synthesized peptide derived from human PI 3 Kinase Class 3 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PIK3C3 (HGNC:8974) |
|---|---|
| Synonyms | VPS34 {ECO:0000305} |
| Function | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). |
| Cellular Location | Midbody. Late endosome. Cytoplasmic vesicle, autophagosome. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity) {ECO:0000250|UniProtKB:Q6PF93, ECO:0000305|PubMed:14617358} |
| Tissue Location | Ubiquitously expressed, with a highest expression in skeletal muscle. |
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$ 370.00
Cat# ABO14263
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