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> home > Products > Primary Antibodies > Signal Transduction > Anti-beta III Tubulin TUBB3 Rabbit Monoclonal Antibody
Anti-beta III Tubulin TUBB3 Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC, IP |
|---|---|
| Primary Accession | Q13509 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-beta III Tubulin TUBB3 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 10381 |
|---|---|
| Other Names | Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III, TUBB3, TUBB4 |
| Calculated MW | 50433 MW KDa |
| Application Details | WB 1:2000-1:20000 IHC 1:50-1:200 ICC/IF 1:50-1:200 IP 1:50 |
| Subcellular Localization | Cytoplasm, cytoskeleton. |
| Tissue Specificity | Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: CB-20 |
| Immunogen | A synthesized peptide derived from human beta III Tubulin |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | TUBB3 |
|---|---|
| Synonyms | TUBB4 |
| Function | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:34996871). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha- tubulin (PubMed:34996871). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9ERD7}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9ERD7} |
| Tissue Location | Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. |
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Application Protocols
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$ 370.00
Cat# ABO14219
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