Anti-14-3-3 gamma YWHAG Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC |
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Primary Accession | P61981 |
Host | Rabbit |
Isotype | Rabbit IgG |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Format | Liquid |
Description | Anti-14-3-3 gamma YWHAG Rabbit Monoclonal Antibody . Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
Gene ID | 7532 |
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Other Names | 14-3-3 protein gamma, Protein kinase C inhibitor protein 1, KCIP-1, 14-3-3 protein gamma, N-terminally processed, YWHAG (HGNC:12852) |
Calculated MW | 28303 MW KDa |
Application Details | WB 1:1000-1:2000 FC 1:50 |
Subcellular Localization | Cytoplasm. |
Tissue Specificity | Highly expressed in brain, skeletal muscle, and heart.. |
Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Clone Names | Clone: HAH-25 |
Immunogen | A synthesized peptide derived from human 14-3-3 gamma |
Purification | Affinity-chromatography |
Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Name | YWHAG (HGNC:12852) |
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Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L- glutamate secretion through interaction with BEST1 (PubMed:29121962). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P68252}. |
Tissue Location | Highly expressed in brain, skeletal muscle, and heart. |
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