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> home > Products > Primary Antibodies > Signal Transduction > Anti-Mitofusin 2 MFN2 Rabbit Monoclonal Antibody
Anti-Mitofusin 2 MFN2 Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC |
|---|---|
| Primary Accession | O95140 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Mitofusin 2 MFN2 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 9927 |
|---|---|
| Other Names | Mitofusin-2, 3.6.5.-, Transmembrane GTPase MFN2, MFN2 {ECO:0000303|PubMed:12598526, ECO:0000312|HGNC:HGNC:16877} |
| Calculated MW | 86402 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 ICC/IF 1:50-1:200 |
| Subcellular Localization | Mitochondrion outer membrane ; Multi- pass membrane protein. Colocalizes with BAX during apoptosis. |
| Tissue Specificity | Ubiquitous; expressed at low level. Highly expressed in heart and kidney.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AOCA-13 |
| Immunogen | A synthesized peptide derived from human Mitofusin 2 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | MFN2 {ECO:0000303|PubMed:12598526, ECO:0000312|HGNC:HGNC:16877} |
|---|---|
| Function | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:19889647, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein Note=Colocalizes with BAX during apoptosis |
| Tissue Location | Ubiquitous; expressed at low level. Highly expressed in heart and kidney. |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO14096
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