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Anti-Cathepsin D CTSD Rabbit Monoclonal Antibody

     
  •  - Anti-Cathepsin D CTSD Rabbit Monoclonal Antibody ABO14075
    All lanes use the Antibody at 1:2W dilution for 1 hour at room temperature.
    detail
  •  - Anti-Cathepsin D CTSD Rabbit Monoclonal Antibody ABO14075
    All lanes use the Antibody at 1:2W dilution for 1 hour at room temperature.
    detail
  •  - Anti-Cathepsin D CTSD Rabbit Monoclonal Antibody ABO14075
    Western blot analysis of Cathepsin D expression in (1)MCF-7 cell lysate;(2)SKBR-3 cell lysate.
    detail
  •  - Anti-Cathepsin D CTSD Rabbit Monoclonal Antibody ABO14075
    Immunohistochemical analysis of paraffin-embedded human ovarian cancer, using Cathepsin D Antibody.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, ICC, IP, FC
Primary Accession P07339
Host Rabbit
Isotype Rabbit IgG
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Format Liquid
Description Anti-Cathepsin D CTSD Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Additional Information
Gene ID 1509
Other Names Cathepsin D, 3.4.23.5, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD
Calculated MW 44552 MW KDa
Application Details WB 1:500-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200
IP 1:50
FC 1:20
Subcellular Localization Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380)..
Tissue Specificity Expressed in the aorta extrcellular space (at protein level)..
Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names Clone: CEF-3
Immunogen A synthesized peptide derived from human Cathepsin D
Purification Affinity-chromatography
Storage Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Information
Name CTSD
Synonyms CPSD
Function Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Cellular Location Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380)
Tissue Location Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
Research Areas
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$ 370.00
Cat# ABO14075
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