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> home > Products > Primary Antibodies > Signal Transduction > Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody
Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | O95832 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 9076 |
|---|---|
| Other Names | Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1 |
| Calculated MW | 22744 MW KDa |
| Application Details | WB 1:500-1:2000 |
| Subcellular Localization | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: ABEH-3 |
| Immunogen | A synthesized peptide derived from human Claudin 1 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | CLDN1 |
|---|---|
| Synonyms | CLD1, SEMP1 |
| Function | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). |
| Cellular Location | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. |
| Tissue Location | Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. |
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$ 370.00
Cat# ABO14010
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