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> home > Products > Primary Antibodies > Cell Biology > Anti-Cyclin D3 CCND3 Rabbit Monoclonal Antibody
Anti-Cyclin D3 CCND3 Rabbit Monoclonal Antibody
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Application 
| WB, IF, ICC, FC |
|---|---|
| Primary Accession | P30281 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Cyclin D3 CCND3 Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse. |
| Gene ID | 896 |
|---|---|
| Other Names | G1/S-specific cyclin-D3, CCND3 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1585} |
| Calculated MW | 32520 MW KDa |
| Application Details | WB 1:1000-1:2000 ICC/IF 1:50-1:200 FC 1:30 |
| Subcellular Localization | Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: GID-3 |
| Immunogen | A synthesized peptide derived from human Cyclin D3 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | CCND3 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1585} |
|---|---|
| Function | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D- CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). |
| Cellular Location | Nucleus. Cytoplasm |
Research Areas
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$ 370.00
Cat# ABO13989
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