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> home > Products > Primary Antibodies > Antibody Collections > Prostate negative > Anti-USP14 Rabbit Monoclonal Antibody
Anti-USP14 Rabbit Monoclonal Antibody
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Application 
| WB, IF, ICC, FC |
|---|---|
| Primary Accession | P54578 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-USP14 Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 9097 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase 14, 3.4.19.12, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14, USP14, TGT |
| Calculated MW | 56069 MW KDa |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 FC 1:60 |
| Subcellular Localization | Cytoplasm. Cell membrane ; Peripheral membrane protein. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: ABGI-21 |
| Immunogen | A synthesized peptide derived from human USP14 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | USP14 |
|---|---|
| Synonyms | TGT |
| Function | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO13803
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