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> home > Products > Primary Antibodies > Signal Transduction > Anti-ERp57 PDIA3 Rabbit Monoclonal Antibody
Anti-ERp57 PDIA3 Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IP |
|---|---|
| Primary Accession | P30101 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-ERp57 PDIA3 Rabbit Monoclonal Antibody . Tested in WB, IHC, IP applications. This antibody reacts with Human. |
| Gene ID | 2923 |
|---|---|
| Other Names | Protein disulfide-isomerase A3, 5.3.4.1, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, p58, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 57, ER protein 57, ERp57, Endoplasmic reticulum resident protein 60, ER protein 60, ERp60, PDIA3 (HGNC:4606), ERP57, ERP60, GRP58 |
| Calculated MW | 56782 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 IP 1:50 |
| Subcellular Localization | Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Detected in the flagellum and head region of spermatozoa (at protein level).. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: ABOE-16 |
| Immunogen | A synthesized peptide derived from human ERp57 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PDIA3 (HGNC:4606) |
|---|---|
| Synonyms | ERP57, ERP60, GRP58 |
| Function | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). |
| Cellular Location | Endoplasmic reticulum. Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:P11598}. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). |
| Tissue Location | Detected in the flagellum and head region of spermatozoa (at protein level) (PubMed:20400973). Expressed in liver, stomach and colon (at protein level). Expressed in gastric parietal cells and chief cells (at protein level) (PubMed:24188822) |
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Application Protocols
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$ 370.00
Cat# ABO13782
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