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Anti-FOXA2/Hnf3B Rabbit Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IF, ICC |
|---|---|
| Primary Accession | Q9Y261 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-FOXA2/Hnf3B Rabbit Monoclonal Antibody . Tested in WB, ICC/IF applications. This antibody reacts with Human. |
| Gene ID | 3170 |
|---|---|
| Other Names | Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2, HNF3B, TCF3B |
| Calculated MW | 48306 MW KDa |
| Application Details | WB 1:500-1:1000 ICC/IF 1:50-1:200 |
| Subcellular Localization | Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AAAH-6 |
| Immunogen | A synthesized peptide derived from human FOXA2 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | FOXA2 |
|---|---|
| Synonyms | HNF3B, TCF3B |
| Function | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta- cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6- induced fibrinogen beta transcriptional activation. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:14500912}. Cytoplasm Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO13760
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