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> home > Products > Primary Antibodies > Signal Transduction > Anti-HMGCR/Hmg Coa Reductase Rabbit Monoclonal Antibody
Anti-HMGCR/Hmg Coa Reductase Rabbit Monoclonal Antibody
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Application 
| WB, IP |
|---|---|
| Primary Accession | P04035 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-HMGCR/Hmg Coa Reductase Rabbit Monoclonal Antibody . Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 3156 |
|---|---|
| Other Names | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, 1.1.1.34, HMGCR (HGNC:5006) |
| Calculated MW | 97476 MW KDa |
| Application Details | WB 1:500-1:2000 IP 1:50 |
| Subcellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AOCC-8 |
| Immunogen | A synthesized peptide derived from human HMGCR |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | HMGCR (HGNC:5006) |
|---|---|
| Function | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. Peroxisome membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347} |
| Tissue Location | [Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland. [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO13738
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