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> home > Products > Primary Antibodies > Signal Transduction > Anti-ABCG1 Rabbit Monoclonal Antibody
Anti-ABCG1 Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC |
|---|---|
| Primary Accession | P45844 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-ABCG1 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Rat. |
| Gene ID | 9619 |
|---|---|
| Other Names | ATP-binding cassette sub-family G member 1, 7.6.2.-, ATP-binding cassette transporter 8, White protein homolog, ABCG1 (HGNC:73), ABC8, WHT1 |
| Calculated MW | 75592 MW KDa |
| Application Details | WB 1:500-1:1000 IHC 1:50-1:100 ICC/IF 1:50-1:100 |
| Subcellular Localization | Endoplasmic reticulum membrane ; Multi-pass membrane protein. Golgi apparatus membrane ; Multi-pass membrane protein. Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. |
| Tissue Specificity | Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: CHH-1 |
| Immunogen | A synthesized peptide derived from human ABCG1 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | ABCG1 (HGNC:73) |
|---|---|
| Synonyms | ABC8, WHT1 |
| Function | Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta- hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta- hydroxycholesterol (PubMed:17408620). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes |
| Tissue Location | Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO13629
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