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Anti-RNF20 Rabbit Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IF, ICC, IP, FC |
|---|---|
| Primary Accession | Q5VTR2 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-RNF20 Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse. |
| Gene ID | 56254 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase BRE1A, BRE1-A, hBRE1, 2.3.2.27, RING finger protein 20, RING-type E3 ubiquitin transferase BRE1A, RNF20, BRE1A |
| Calculated MW | 113662 MW KDa |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 IP 1:50 FC 1:50 |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Expressed in the normal brain and also in malignant gliomas (at protein level).. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: FC-18 |
| Immunogen | A synthesized peptide derived from human RNF20 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | RNF20 |
|---|---|
| Synonyms | BRE1A |
| Function | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. |
| Cellular Location | Nucleus |
| Tissue Location | Expressed in the normal brain and also in malignant gliomas (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO13572
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