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> home > Products > Primary Antibodies > Signal Transduction > Anti-MRP1 ABCC1 Rabbit Monoclonal Antibody
Anti-MRP1 ABCC1 Rabbit Monoclonal Antibody
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Application 
| WB, FC |
|---|---|
| Primary Accession | P33527 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-MRP1 ABCC1 Rabbit Monoclonal Antibody . Tested in WB, Flow Cytometry applications. This antibody reacts with Human. |
| Gene ID | 4363 |
|---|---|
| Other Names | Multidrug resistance-associated protein 1, 7.6.2.2, ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, LTC4 transporter, ABCC1 (HGNC:51), MRP, MRP1 |
| Calculated MW | 171591 MW KDa |
| Application Details | WB 1:500-1:2000 FC 1:20 |
| Subcellular Localization | Cell membrane ; Multi-pass membrane protein. |
| Tissue Specificity | Lung, testis and peripheral blood mononuclear cells. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: ABFD-1 |
| Immunogen | A synthesized peptide derived from human MRP1 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | ABCC1 (HGNC:51) |
|---|---|
| Synonyms | MRP, MRP1 |
| Function | Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17- beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Mediates ATP- dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:16230346} |
| Tissue Location | Lung, testis and peripheral blood mononuclear cells |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO13561
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