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> home > Products > Primary Antibodies > Signal Transduction > Anti-MRP2 ABCC2 Rabbit Monoclonal Antibody
Anti-MRP2 ABCC2 Rabbit Monoclonal Antibody
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Application 
| WB, IF, ICC, FC |
|---|---|
| Primary Accession | Q92887 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-MRP2 ABCC2 Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human. |
| Gene ID | 1244 |
|---|---|
| Other Names | ATP-binding cassette sub-family C member 2, 7.6.2.-, 7.6.2.2, 7.6.2.3, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, Multidrug resistance-associated protein 2, ABCC2 (HGNC:53) |
| Calculated MW | 174207 MW KDa |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 FC 1:100 |
| Subcellular Localization | Apical cell membrane ; Multi-pass membrane protein. |
| Tissue Specificity | Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: ABDD-1 |
| Immunogen | A synthesized peptide derived from human MRP2 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | ABCC2 (HGNC:53) |
|---|---|
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)- conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17- glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Note=Localized to the apical membrane of enterocytes |
| Tissue Location | Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine (PubMed:28408210). |
Research Areas
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$ 370.00
Cat# ABO13557
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