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Anti-Noxa Rabbit Monoclonal Antibody
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q13794 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Noxa Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse. |
| Gene ID | 5366 |
|---|---|
| Other Names | Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa, PMAIP1, NOXA |
| Calculated MW | 6030 MW KDa |
| Application Details | WB 1:500-1:2000 |
| Subcellular Localization | Mitochondrion. |
| Tissue Specificity | Highly expressed in adult T-cell leukemia cell line. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AAFB-16 |
| Immunogen | A synthesized peptide derived from human Noxa |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PMAIP1 |
|---|---|
| Synonyms | NOXA |
| Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
| Cellular Location | Mitochondrion |
| Tissue Location | Highly expressed in adult T-cell leukemia cell line |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO13537
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