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> home > Products > Primary Antibodies > Signal Transduction > Anti-TRX1 TXN Rabbit Monoclonal Antibody
Anti-TRX1 TXN Rabbit Monoclonal Antibody
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Application 
| WB, FC |
|---|---|
| Primary Accession | P10599 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-TRX1 TXN Rabbit Monoclonal Antibody . Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 7295 |
|---|---|
| Other Names | Thioredoxin, Trx, ATL-derived factor, ADF, Surface-associated sulphydryl protein, SASP, Hom s Trx, TXN, TRDX, TRX, TRX1 |
| Calculated MW | 11737 MW KDa |
| Application Details | WB 1:1000-1:5000 FC 1:100 |
| Subcellular Localization | Nucleus. Cytoplasm. Secreted. Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AOGB-20 |
| Immunogen | A synthesized peptide derived from human TRX1 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | TXN |
|---|---|
| Synonyms | TRDX, TRX, TRX1 |
| Function | Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the reversible S- nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:11118054, PubMed:9108029). |
| Cellular Location | Nucleus. Cytoplasm. Secreted Note=Translocates from the cytoplasm into the nucleus after phorbol 12- myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). |
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Application Protocols
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$ 370.00
Cat# ABO13512
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