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Anti-DKK1 Rabbit Monoclonal Antibody

     
  •  - Anti-DKK1 Rabbit Monoclonal Antibody ABO13423
    All lanes use the Antibody at 1:5K dilution for 1 hour at room temperature.
    detail
  •  - Anti-DKK1 Rabbit Monoclonal Antibody ABO13423
    All lanes use the Antibody at 1:5K dilution for 1 hour at room temperature.
    detail
  •  - Anti-DKK1 Rabbit Monoclonal Antibody ABO13423
    Western blot analysis of DKK1 expression in HeLa cell lysate.
    detail
  •  - Anti-DKK1 Rabbit Monoclonal Antibody ABO13423
    Immunohistochemical analysis of paraffin-embedded human placenta, using DKK1 Antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, ICC, FC
Primary Accession O94907
Host Rabbit
Isotype Rabbit IgG
Reactivity Rat, Human
Clonality Monoclonal
Format Liquid
Description Anti-DKK1 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Rat.
Additional Information
Gene ID 22943
Other Names Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1
Calculated MW 28672 MW KDa
Application Details WB 1:1000-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200
FC 1:50
Subcellular Localization Secreted.
Tissue Specificity Placenta.
Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Clone Names Clone: FHG-4
Immunogen A synthesized peptide derived from human DKK1
Purification Affinity-chromatography
Storage Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Information
Name DKK1
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Cellular Location Secreted.
Tissue Location Placenta.
Research Areas
Citations (0)
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$ 370.00
Cat# ABO13423
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