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> home > Products > Primary Antibodies > Antibody Collections > Endometrium positive > Anti-IDE/Insulysin Rabbit Monoclonal Antibody
Anti-IDE/Insulysin Rabbit Monoclonal Antibody
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Application 
| WB, IHC |
|---|---|
| Primary Accession | P14735 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-IDE/Insulysin Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 3416 |
|---|---|
| Other Names | Insulin-degrading enzyme, 3.4.24.56, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin, IDE {ECO:0000303|PubMed:20364150, ECO:0000312|HGNC:HGNC:5381} |
| Calculated MW | 117968 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:100 |
| Subcellular Localization | Cytoplasm. Cell membrane. Secreted. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AOOB-9 |
| Immunogen | A synthesized peptide derived from human IDE |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | IDE {ECO:0000303|PubMed:20364150, ECO:0000312|HGNC:HGNC:5381} |
|---|---|
| Function | Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:10684867, PubMed:17051221, PubMed:17613531, PubMed:18986166, PubMed:19321446, PubMed:21098034, PubMed:2293021, PubMed:23922390, PubMed:24847884, PubMed:26394692, PubMed:26968463, PubMed:29596046). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (PubMed:23922390, PubMed:26394692, PubMed:29596046). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (Probable) (PubMed:26394692, PubMed:9830016). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (PubMed:21098034). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (PubMed:21098034). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I. |
| Cellular Location | Cytoplasm, cytosol. Cell membrane {ECO:0000250|UniProtKB:P35559}. Secreted Note=Present at the cell surface of neuron cells. The membrane- associated isoform is approximately 5 kDa larger than the known cytosolic isoform |
| Tissue Location | Detected in brain and in cerebrospinal fluid (at protein level). |
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$ 370.00
Cat# ABO13269
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