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> home > Products > Primary Antibodies > Signal Transduction > Anti-Phospho-GCN2 (T899) EIF2AK4 Rabbit Monoclonal Antibody
Anti-Phospho-GCN2 (T899) EIF2AK4 Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q9P2K8 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Phospho-GCN2 (T899) EIF2AK4 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human. |
| Gene ID | 440275 |
|---|---|
| Other Names | eIF-2-alpha kinase GCN2, GCN2-like protein, EIF2AK4 (HGNC:19687), GCN2, KIAA1338 |
| Calculated MW | 186911 MW KDa |
| Application Details | WB 1:500-1:2000 |
| Tissue Specificity | Widely expressed. Expressed in the lung in smooth muscle cells of the pulmonary vessel wall, interstitial tissue and macrophages.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: ABH-5 |
| Immunogen | A synthesized peptide derived from human Phospho-GCN2 (T899) |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | EIF2AK4 (HGNC:19687) |
|---|---|
| Synonyms | GCN2, KIAA1338 |
| Function | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR- specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9QZ05}. |
| Tissue Location | Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273) |
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$ 370.00
Cat# ABO13124
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