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Anti-NMU Picoband Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P48645 |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for NMU detection. Tested with WB in Human;Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 10874 |
|---|---|
| Other Names | Neuromedin-U, Neuromedin-U-25, NmU-25, NMU |
| Calculated MW | 19741 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Expressed throughout the enteric nervous system with highest levels being found in the jejunum. |
| Contents | Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence of human NMU (FRVDEEFQSPFASQSRGYFLFRPRN). |
| Cross Reactivity | No cross reactivity with other proteins. |
| Storage | At -20˚C; for one year. After r˚Constitution, at 4˚C; for one month. It˚Can also be aliquotted and stored frozen at -20˚C; for a longer time. Avoid repeated freezing and thawing. |
| Name | NMU |
|---|---|
| Function | [Neuromedin-U-25]: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed throughout the enteric nervous system with highest levels being found in the jejunum |
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Provided below are standard protocols that you may find useful for product applications.
Background
Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle, which was isolated first from porcine spinal cord and later from other species. It is a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide.
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