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Anti-ALDH3A2 Picoband Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P51648 |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Fatty aldehyde dehydrogenase(ALDH3A2) detection. Tested with WB, IHC-P in Human;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 224 |
|---|---|
| Other Names | Fatty aldehyde dehydrogenase, 1.2.1.3, Aldehyde dehydrogenase 10, Aldehyde dehydrogenase family 3 member A2, Microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10, FALDH |
| Calculated MW | 54848 MW KDa |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat Western blot, 0.1-0.5 µg/ml, Human, Rat |
| Subcellular Localization | Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side . |
| Protein Name | Fatty aldehyde dehydrogenase |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Immunogen | E.coli-derived human ALDH3A2 recombinant protein (Position: M1-Q100). Human ALDH3A2 shares 78% amino acid (aa) sequence identity with both mouse and rat ALDH3A2. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Name | ALDH3A2 |
|---|---|
| Function | Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:18035827, PubMed:18182499, PubMed:22633490, PubMed:25047030, PubMed:9133646, PubMed:9662422). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). |
| Cellular Location | Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:P30839} |
| Tissue Location | Detected in liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Fatty aldehyde dehydrogenase (or Long-chain-aldehyde dehydrogenase) is an aldehyde dehydrogenase enzyme that in human is encoded in the ALDH3A2 gene on chromosome 17. ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes into fatty acids. It is known to act on a variety of both saturated and unsaturated aliphatic aldehydes between 6 to 24 carbons in length, as well as dihydrophytal, a 20-carbon branched chain aldehyde. It requires NAD+ as a co-factor. The encoded enzyme is responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. ALD3H2 is expressed in the human liver and has been found to localize the microsome fraction inside the cell.
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