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Anti-CMA1 Picoband Antibody

     
  • IHC - Anti-CMA1 Picoband Antibody ABO11774
    Anti-CMA1 Picoband antibody, ABO11774-1.JPGIHC(P): Human Placenta Tissue
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  • WB - Anti-CMA1 Picoband Antibody ABO11774
    Anti-CMA1 Picoband antibody, ABO11774-2.jpgAll lanes: Anti-CMA1(ABO11774) at 0.5ug/mlWB: Recombinant Human CMA1 Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P23946
Host Rabbit
Reactivity Human
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Chymase(CMA1) detection. Tested with WB, IHC-P in Human.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 1215
Other Names Chymase, 3.4.21.39, Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM
Calculated MW 27325 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat
Western blot, 0.1-0.5 µg/ml, Human
Subcellular Localization Secreted. Cytoplasmic granule. Mast cell granules.
Tissue Specificity Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. .
Protein Name Chymase
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E.coli-derived human CMA1 recombinant protein (Position: I22-N247). Human CMA1 shares 75% and 74% amino acid (aa) sequences identity with mouse and rat CMA1, respectively.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the peptidase S1 family. Granzyme subfamily.
Protein Information
Name CMA1
Synonyms CYH, CYM
Function Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Cellular Location Secreted. Cytoplasmic granule. Note=Mast cell granules
Tissue Location Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions
Research Areas
Citations (0)
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Background

Chymase is a major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. Chymase is mapped to 14q12. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II.

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$ 370.00
Cat# ABO11774
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