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Anti-ADAM19 Antibody

     
  • WB - Anti-ADAM19 Antibody ABO11376
    Anti-ADAM19 antibody, ABO11376, Western blottingLane 1: Rat Spleen Tissue LysateLane 2: Rat Intestine Tissue LysateLane 3: Rat Brain Tissue LysateLane 4: HELA Cell Lysate
    detail
  • IHC - Anti-ADAM19 Antibody ABO11376
    Anti-ADAM19 antibody, ABO11376, IHC(P)IHC(P): Rat Spleen Tissue
    detail
  • IHC - Anti-ADAM19 Antibody ABO11376
    Anti-ADAM19 antibody, ABO11376, IHC(P)IHC(P): Human Lung Cancer Tissue
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9H013
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Disintegrin and metalloproteinase domain-containing protein 19(ADAM19) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 8728
Other Names Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, 3.4.24.-, Meltrin-beta, Metalloprotease and disintegrin dendritic antigen marker, MADDAM, ADAM19, MLTNB
Calculated MW 104997 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse
Subcellular Localization Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in many normal organ tissues and several cancer cell lines.
Protein Name Disintegrin and metalloproteinase domain-containing protein 19
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human ADAM19(286-298aa RRKLLAQKYHDNA), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Contains 1 disintegrin domain.
Protein Information
Name ADAM19
Synonyms MLTNB
Function Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Expressed in many normal organ tissues and several cancer cell lines
Research Areas
Citations (0)
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Background

ADAM19(A Disintegrin and Metalloproteinase Domain 19), also known as MLTNB, is a human gene. This gene encodes a member of the ADAM(a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Hirohata et al.(1998) used radiation hybrids to map ADAM19 to mouse chromosome 11 and to human chromosome 5q32-q33.

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$ 370.00
Cat# ABO11376
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