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Anti-Transferrin Receptor 2 Antibody
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9JKX3 |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Transferrin receptor protein 2(TFR2) detection. Tested with WB in Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 50765 |
|---|---|
| Other Names | Transferrin receptor protein 2, TfR2, Tfr2, Trfr2 |
| Calculated MW | 88402 MW KDa |
| Application Details | Western blot, 0.1-0.5 µg/ml, Mouse, Rat |
| Subcellular Localization | Cell membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart. |
| Protein Name | Transferrin receptor protein 2 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of mouse Transferrin Receptor 2(1-15aa MEQRWGLLRRVQQWS), different from the related rat sequence by one amino acid. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Name | Tfr2 |
|---|---|
| Synonyms | Trfr2 |
| Function | Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
TFR2(Transferrin receptor protein 2), is a protein that in humans is encoded by the TFR2 gene. This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated(PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. By radiation hybrid analysis, Kawabata et al.(1999) mapped the TFR2 gene to chromosome 7q22.The majority of hepatic iron uptake under normal circumstances is transferrin-mediated. However, expression of TFRC in hepatocytes, as in other nonreticuloendothelial cell types, is downregulated in response to increased intracellular iron. As a consequence, TFRC expression in liver is undetectable in hereditary hemochromatosis patients with hepatic iron loading. Nonetheless, hepatic iron loading in hemochromatosis patients is progressive. Fleming et al.(2000) provided support for a mechanism that involves the uptake of transferrin-bound iron by TFR2.
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