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Anti-ERBB3/Her3 Antibody

     
  • WB - Anti-ERBB3/Her3 Antibody ABO11187
    Anti-ErbB 3 antibody, ABO11187, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human ERBB3, 45.0KD(162aa tag+ M1-A245)Lane 1: Recombinant Human ERBB3 Protein 5ngLane 2: Recombinant Human ERBB3 Protein 2.5ngLane 3: Recombinant Human ERBB3 Protein 1.25ng
    detail
Anti-ErbB 3 antibody, ABO11187, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human ERBB3, 45.0KD(162aa tag+ M1-A245)Lane 1: Recombinant Human ERBB3 Protein 5ngLane 2: Recombinant Human ERBB3 Protein 2.5ngLane 3: Recombinant Human ERBB3 Protein 1.25ng
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P21860
Host Rabbit
Reactivity Human
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-3(ERBB3) detection. Tested with WB in Human.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 2065
Other Names Receptor tyrosine-protein kinase erbB-3, 2.7.10.1, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Calculated MW 148098 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Human
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Epithelial tissues and brain.
Protein Name Receptor tyrosine-protein kinase erbB-3
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 3(162-181aa DWRDIVRDRDAEIVVKDNGR).
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Protein Information
Name ERBB3
Synonyms HER3
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).
Cellular Location [Isoform 1]: Cell membrane; Single-pass type I membrane protein
Tissue Location Epithelial tissues and brain.
Research Areas
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$ 370.00
Cat# ABO11187
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