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Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16)

     
  • IHC - Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16) ABO10484
    Anti- Tyrosine Hydroxylase antibody, ABO10484, IHC(P)IHC(P): Rat Brain Tissue
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-F
Primary Accession P04177
Host Mouse
Isotype Mouse IgG1
Reactivity Human, Rat
Clonality Monoclonal
Format Lyophilized
Description Mouse IgG monoclonal antibody for Tyrosine Hydroxylase, tyrosine hydroxylase (TH) detection. Tested with WB, IHC-P, IHC-F in Human;rat;rabbit. No cross reactivity with other proteins.
Reconstitution Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Additional Information
Gene ID 25085
Other Names Tyrosine 3-monooxygenase, 1.14.16.2, Tyrosine 3-hydroxylase, TH, Th
Calculated MW 55966 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, rat, rabbit, By Heat

Immunohistochemistry(Frozen Section), 0.5-1 µg/ml, Human, rat, rabbit, -
Western blot, 0.25-0.5 µg/ml, Human, rat, rabbit
Tissue Specificity TH: Mainly expressed in the brain and adrenalglands.
Protein Name Tyrosine 3-monooxygenase
Contents Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Clone Names TH-16
Immunogen Rat tyrosine hydroxylase(TH).
Purification Ascites
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Protein Information
Name Th
Function Catalyzes the conversion of L-tyrosine to L- dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity (PubMed:10933781, PubMed:11922614). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).
Cellular Location Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P24529}. Nucleus Cell projection, axon {ECO:0000250|UniProtKB:P24529}. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well as at Ser-40 shows a cytosolic distribution (PubMed:21392500). Expressed in dopaminergic axons and axon terminals (By similarity) {ECO:0000250|UniProtKB:P07101, ECO:0000269|PubMed:21392500}
Research Areas
Citations (0)
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Background

Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Human TH gene contains 13 primary exons and spans approximately 8 kb. TH is in the 11p15.5 region.

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$ 370.00
Cat# ABO10484
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