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Anti-Pan-Cadherin Antibody (Monoclonal, CH-19)
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | F1LMI3 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Pan-Cadherin, cadherin 1, type 1, E-cadherin (epithelial); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental) (CDH1; CDH2; CDH3 ) detection. Tested with WB, IHC-P in Human;mouse;rat;rabbit;chicken;snake. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Calculated MW | 90415 MW KDa |
|---|---|
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 2-4 µg/ml, Human, mouse, rat, rabbit, chicken, snake., By Heat Western blot, 1-2 µg/ml, Human, mouse, rat, rabbit, chicken, snake. |
| Subcellular Localization | CDH1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome. Golgi apparatus, trans-Golginetwork. Note: Colocalizes with DLGAP5 at sites of cell-cellcontact in intestinal epithelial cells. Anchored to actinmicrofilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calciuminflux, results in translocation from sites of cell-cell contactto the cytoplasm. Colocalizes with RAB11A endosomes during itstransport from the Golgi apparatus to the plasma membrane.|Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus,trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-,beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity). |Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus,trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-,beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity). |CDH2: Cell membrane; Single-pass type I membraneprotein.|Cdh2: Cell membrane; Single-pass type I membraneprotein.|Cdh2: Cell membrane |CDH3: Cell membrane; Single-pass type I membraneprotein.|Cdh3: Cell membrane; Single-pass type I membraneprotein. |
| Tissue Specificity | CDH1: Non-neural epithelial tissues. |
| Protein Name | Cadherin-1; Cadherin-2; Cadherin-3 |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | CH-19 |
| Immunogen | Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue(24 amino acids) coupled to KLH. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Contains 5 cadherin domains. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherin expression is regulated spatially as well as temporally. Cadherins are though to play an important role in development and maintenance of tissues through selective cell-cell adhesion activity and may be involved also in the invasion and metastasis of malignant tumors. Cadherin regulates dendritic spine morphogenesis. A cadherin gene cluster is mapped to a region of chromosome 5 subject to frequent allelic loss in carcinoma.
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