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Anti-Anterior Gradient 2 Picoband Antibody

     
  • WB - Anti-Anterior Gradient 2 Picoband Antibody ABO10267
    Western blot analysis of Anterior Gradient 2 expression in rat lung extract (lane 1), mouse liver extract (lane 2) and MCF-7 whole cell lysates (lane 3). Anterior Gradient 2 at 20KD was detected using rabbit anti- Anterior Gradient 2 Antigen Affinity purified polyclonal antibody (Catalog # ABO10267) at 0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method .
    detail
  • IHC - Anti-Anterior Gradient 2 Picoband Antibody ABO10267
    Anterior Gradient 2 was detected in paraffin-embedded sections of mouse intestine tissues using rabbit anti- Anterior Gradient 2 Antigen Affinity purified polyclonal antibody (Catalog # ABO10267) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-Anterior Gradient 2 Picoband Antibody ABO10267
    Anterior Gradient 2 was detected in paraffin-embedded sections of rat intestine tissues using rabbit anti- Anterior Gradient 2 Antigen Affinity purified polyclonal antibody (Catalog # ABO10267) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-Anterior Gradient 2 Picoband Antibody ABO10267
    Anterior Gradient 2 was detected in paraffin-embedded sections of human tonsil tissues using rabbit anti- Anterior Gradient 2 Antigen Affinity purified polyclonal antibody (Catalog # ABO10267) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-Anterior Gradient 2 Picoband Antibody ABO10267
    Anterior Gradient 2 was detected in paraffin-embedded sections of human lung cancer tissues using rabbit anti- Anterior Gradient 2 Antigen Affinity purified polyclonal antibody (Catalog # ABO10267) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O95994
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Anterior gradient protein 2 homolog(AGR2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 10551
Other Names Anterior gradient protein 2 homolog, AG-2, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog, AGR2, AG2
Calculated MW 19979 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat

Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Secreted . Endoplasmic reticulum .
Tissue Specificity Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. .
Protein Name Anterior gradient protein 2 homolog
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E.coli-derived human Anterior Gradient 2 recombinant protein (Position: R21-L175). Human Anterior Gradient 2 shares 93.5% amino acid (aa) sequence identity with mouse Anterior Gradient 2.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name AGR2
Synonyms AG2
Function Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).
Cellular Location Secreted. Endoplasmic reticulum {ECO:0000250|UniProtKB:O88312}
Tissue Location Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines
Research Areas
Citations (0)
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Background

Anterior gradient protein 2 homolog (AGR-2), also known as secreted cement gland protein XAG-2 homolog, is a protein that in humans is encoded by the AGR2 gene. Anterior gradient homolog 2 was originally discovered in Xenopus laevis. In Xenopus AGR2 plays a role in cement gland differentiation, but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response, cell migration, and cell transformation. However, there have been other observations that AGR2 can repress growth and proliferation.

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$ 370.00
Cat# ABO10267
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