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Anti-Cytokeratin 18 Picoband Antibody

     
  • WB - Anti-Cytokeratin 18 Picoband Antibody ABO10178
    Western blot analysis of Cytokeratin 18 expression in rat liver extract (lane 1), mouse liver extract (lane 2), HELA whole cell lysates (lane 3) and HEPG2 whole cell lysates (lane 4). Cytokeratin 18 at 55KD was detected using rabbit anti- Cytokeratin 18 Antigen Affinity purified polyclonal antibody (Catalog # ABO10178) at 0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method .
    detail
  • IHC - Anti-Cytokeratin 18 Picoband Antibody ABO10178
    Cytokeratin 18 was detected in paraffin-embedded sections of mouse intestine tissues using rabbit anti- Cytokeratin 18 Antigen Affinity purified polyclonal antibody (Catalog # ABO10178) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-Cytokeratin 18 Picoband Antibody ABO10178
    Cytokeratin 18 was detected in paraffin-embedded sections of mouse kidney tissues using rabbit anti- Cytokeratin 18 Antigen Affinity purified polyclonal antibody (Catalog # ABO10178) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-Cytokeratin 18 Picoband Antibody ABO10178
    Cytokeratin 18 was detected in paraffin-embedded sections of rat intestine tissues using rabbit anti- Cytokeratin 18 Antigen Affinity purified polyclonal antibody (Catalog # ABO10178) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-Cytokeratin 18 Picoband Antibody ABO10178
    Cytokeratin 18 was detected in paraffin-embedded sections of rat kidney tissues using rabbit anti- Cytokeratin 18 Antigen Affinity purified polyclonal antibody (Catalog # ABO10178) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-Cytokeratin 18 Picoband Antibody ABO10178
    Cytokeratin 18 was detected in paraffin-embedded sections of human intetsinal cancer tissues using rabbit anti- Cytokeratin 18 Antigen Affinity purified polyclonal antibody (Catalog # ABO10178) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-Cytokeratin 18 Picoband Antibody ABO10178
    Cytokeratin 18 was detected in paraffin-embedded sections of human placenta tissues using rabbit anti- Cytokeratin 18 Antigen Affinity purified polyclonal antibody (Catalog # ABO10178) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P05783
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Keratin, type I cytoskeletal 18(KRT18) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 3875
Other Names Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18
Calculated MW 48058 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat

Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Cytoplasm, perinuclear region. Nucleus, nucleolus.
Tissue Specificity Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. .
Protein Name Keratin, type I cytoskeletal 18
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E.coli-derived human Cytokeratin 18 recombinant protein (Position: E204-H430). Human Cytokeratin 18 shares 87.7% and 85.9% amino acid (aa) sequence identity with mouse and rat Cytokeratin 18, respectively.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name KRT18
Synonyms CYK18
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Cellular Location Nucleus matrix {ECO:0000250|UniProtKB:Q5BJY9}. Cytoplasm, perinuclear region. Nucleus, nucleolus. Cytoplasm {ECO:0000250|UniProtKB:Q5BJY9}
Tissue Location Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Research Areas
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Background

Keratin 18, mapped to 12q13.13, is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

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$ 370.00
Cat# ABO10178
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